PROTAC CDK6 Degrader 1

Produktübersicht

• Artikelname: PROTAC CDK6 Degrader 1
• Artikelnummer: MCE-HY-180277
• Hersteller Artikelnummer: HY-180277
• Alternativnummer: MCE-HY-180277-5MG, MCE-HY-180277-10MG, MCE-HY-180277-25MG, MCE-HY-180277-50MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC CDK6 Degrader 1 (compound 48a) is a potent and selective PROTAC CDK6 degrader with a DC50 of 0.037 µM. PROTAC CDK6 Degrader 1 exhibits selectivity over CDK4 (DC50 > 10 µM). PROTAC CDK6 Degrader 1 induces G0/G1 cell-cycle arrest and apoptosis through inhibition of CDK6 downstream signaling. PROTAC CDK6 Degrader 1 reduces tumor burden and CDK6 levels in a MOLM-14 xenograft mouse model. PROTAC CDK6 Degrader 1 can be used for CDK6-driven cancers research, such as acute myeloid leukemia (AML)[1].

Produkteigenschaften

• Molekulargewicht: 1268.55
• Formel: C70H89N15O8
• Target-Kategorie: Apoptosis,CDK,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound