PROTAC CDK6 Degrader 1 (compound 48a) is a potent and selective PROTAC CDK6 degrader with a DC50 of 0.037 µM. PROTAC CDK6 Degrader 1 exhibits selectivity over CDK4 (DC50 > 10 µM). PROTAC CDK6 Degrader 1 induces G0/G1 cell-cycle arrest and apoptosis through inhibition of CDK6 downstream signaling. PROTAC CDK6 Degrader 1 reduces tumor burden and CDK6 levels in a MOLM-14 xenograft mouse model. PROTAC CDK6 Degrader 1 can be used for CDK6-driven cancers research, such as acute myeloid leukemia (AML)[1].
Molecular Weight:
1268.55
Formula:
C70H89N15O8
Target:
Apoptosis,CDK,PROTACs
Application Notes:
MCE Product type: Reference compound
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