Tan-931 is a non-competitive and selective inhibitor of aromatase , with an IC50 is 17.2 µM and a Ki of 40 µM for human aromatase, and an IC50 of 162 µM for rat aromatase. Tan-931 reduces plasma estradiol-17beta level and weight of ovaries and uterus in PMSG (HY-N12634)-treated female rats. Tan-931 can be used for the research of estrogen-dependent metastatic breast cancer[1][2].
Molekulargewicht:
302.24
CAS Nummer:
[127448-92-4]
Formel:
C15H10O7
Target-Kategorie:
Cytochrome P450
Anwendungsbeschreibung:
MCE Product type: Reference compound
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