SN38-(PEG)2-Pom-alpha is a selective PROTAC RPL15 degrader. SN38-(PEG)2-Pom-alpha induces ubiquitin-mediated degradation of RPL15 without affecting TOP1. SN38-(PEG)2-Pom-alpha induces damage-associated molecular pattern (DAMP) secretion from cancer cells, which activated cGAS-STING signaling in dendritic cells. SN38-(PEG)2-Pom-alpha enhances anti-PD-1 immunotherapy in a murine melanoma tumor model expressing human CRBN. SN38-(PEG)2-Pom-alpha can be used for melanoma research[1].
Molekulargewicht:
918.90
Formel:
C46H46N8O13
Target-Kategorie:
PROTACs,STING
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
