SN38-(PEG)2-Pom-alpha is a selective PROTAC RPL15 degrader. SN38-(PEG)2-Pom-alpha induces ubiquitin-mediated degradation of RPL15 without affecting TOP1. SN38-(PEG)2-Pom-alpha induces damage-associated molecular pattern (DAMP) secretion from cancer cells, which activated cGAS-STING signaling in dendritic cells. SN38-(PEG)2-Pom-alpha enhances anti-PD-1 immunotherapy in a murine melanoma tumor model expressing human CRBN. SN38-(PEG)2-Pom-alpha can be used for melanoma research[1].
Molecular Weight:
918.90
Formula:
C46H46N8O13
Target:
PROTACs,STING
Application Notes:
MCE Product type: Reference compound
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