WWQ-03-012, CAS [[3076807-15-0]]

Produktübersicht

• Artikelname: WWQ-03-012, CAS [[3076807-15-0]]
• Artikelnummer: MCE-HY-180561
• Hersteller Artikelnummer: HY-180561
• Alternativnummer: MCE-HY-180561-10MG, MCE-HY-180561-25MG, MCE-HY-180561-50MG, MCE-HY-180561-100MG, MCE-HY-180561-5MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

WWQ-03-012 is a selective deSUMOylating isopeptidases DESI2 inhibitor with an IC50 of 47.3 µM. WWQ-03-012 cans induce JAK2-V617F ubiquitination-proteasome degradation with no significant effect on wild-type JAK2. WWQ-03-012 can block JAK2-STAT3/5 signaling, inhibit cell proliferation and induce apoptosis. WWQ-03-012 has a synergistic effect in combination with Ruxolitinib (HY-50856), further enhancing its killing effect on JAK2 mutant cells. WWQ-03-012 can be used for the research of cancer, such as myeloproliferative neoplasms[1].

Produkteigenschaften

• Molekulargewicht: 392.43
• CAS Nummer: [3076807-15-0]
• Formel: C20H16N4O3S
• Target-Kategorie: Apoptosis,Deubiquitinase,JAK,STAT

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound