WWQ-03-012, CAS [[3076807-15-0]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-180561
Supplier Catalog Number:
HY-180561
Alternative Catalog Number:
MCE-HY-180561-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
WWQ-03-012 is a selective deSUMOylating isopeptidases DESI2 inhibitor with an IC50 of 47.3 µM. WWQ-03-012 cans induce JAK2-V617F ubiquitination-proteasome degradation with no significant effect on wild-type JAK2. WWQ-03-012 can block JAK2-STAT3/5 signaling, inhibit cell proliferation and induce apoptosis. WWQ-03-012 has a synergistic effect in combination with Ruxolitinib (HY-50856), further enhancing its killing effect on JAK2 mutant cells. WWQ-03-012 can be used for the research of cancer, such as myeloproliferative neoplasms[1].
Molecular Weight:
392.43
CAS Number:
[3076807-15-0]
Formula:
C20H16N4O3S
Target:
Apoptosis,Deubiquitinase,JAK,STAT
Application Notes:
MCE Product type: Reference compound
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