BI-9627 (hydrochloride), CAS [[1422252-46-7]]

Produktübersicht

• Artikelname: BI-9627 (hydrochloride), CAS [[1422252-46-7]]
• Artikelnummer: MCE-HY-18071A
• Hersteller Artikelnummer: HY-18071A
• Alternativnummer: MCE-HY-18071A-50MG,MCE-HY-18071A-10MG,MCE-HY-18071A-25MG,MCE-HY-18071A-10MMX1ML,MCE-HY-18071A-5MG,MCE-HY-18071A-100MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

BI-9627 hydrochloride is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor (IC50 = 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays). BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride decreases autophagy in HTR-8/SVneo cells. BI-9627 hydrochloride can significantly reduce the pHi of human sperm and partially reverse the effect of DMA. BI-9627 hydrochloride prolongs Ca2+ recovery time in KO hiPSC-CMs. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury[1][2][3][4].

Produkteigenschaften

• Molekulargewicht: 392.80
• Reinheit: 98.01
• CAS Nummer: [1422252-46-7]
• Formel: C16H20ClF3N4O2
• Target-Kategorie: Autophagy,Na+/H+ Exchanger (NHE)

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound