BI-9627 (hydrochloride), CAS [[1422252-46-7]]

Product Overview

• Article Name: BI-9627 (hydrochloride), CAS [[1422252-46-7]]
• Biozol Catalog Number: MCE-HY-18071A
• Supplier Catalog Number: HY-18071A
• Alternative Catalog Number: MCE-HY-18071A-50MG,MCE-HY-18071A-10MG,MCE-HY-18071A-25MG,MCE-HY-18071A-10MMX1ML,MCE-HY-18071A-5MG,MCE-HY-18071A-100MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

BI-9627 hydrochloride is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor (IC50 = 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays). BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride decreases autophagy in HTR-8/SVneo cells. BI-9627 hydrochloride can significantly reduce the pHi of human sperm and partially reverse the effect of DMA. BI-9627 hydrochloride prolongs Ca2+ recovery time in KO hiPSC-CMs. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury[1][2][3][4].

Product Properties

• Molecular Weight: 392.80
• Purity: 98.01
• CAS Number: [1422252-46-7]
• Formula: C16H20ClF3N4O2
• Target: Autophagy,Na+/H+ Exchanger (NHE)

Application Notes

• Application Notes: MCE Product type: Reference compound