ERB-2 is a selective ERbeta PROTAC degrader. ERB-2 removes the inhibitory effect of ERbeta on ROS, leading to the accumulation of ROS, mitochondrial damage, and ultimately triggering cell apoptosis (apoptosis). ERB-2 significantly inhibits tumor growth in the nude mouse model of NCI-H1975OR tumors. ERB-2 can be used for the study of non-small cell lung cancer[1].
Molekulargewicht:
886.02
Formel:
C46H55N5O11S
Target-Kategorie:
Apoptosis,Estrogen Receptor/ERR,PROTACs,Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
