ERB-2 is a selective ERbeta PROTAC degrader. ERB-2 removes the inhibitory effect of ERbeta on ROS, leading to the accumulation of ROS, mitochondrial damage, and ultimately triggering cell apoptosis (apoptosis). ERB-2 significantly inhibits tumor growth in the nude mouse model of NCI-H1975OR tumors. ERB-2 can be used for the study of non-small cell lung cancer[1].
Molecular Weight:
886.02
Formula:
C46H55N5O11S
Target:
Apoptosis,Estrogen Receptor/ERR,PROTACs,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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