S1RA (E-52862) is a highly selective sigma1 receptor (sigma1R) antagonist with Kis of 17 nM and 23.5 nM for human sigma1R and guinea pig sigma1R, respectively. S1RA has Moderate antagonistic activity for human 5-HT2B receptor (Ki= 328 nM). S1RA has antinociceptive effects in neuropathic pain models. S1RA prevents mechanical and cold hypersensitivity in Oxaliplatin (HY-17371)-treated mice[1][2].
Molekulargewicht:
337.42
Reinheit:
99.43
CAS Nummer:
[878141-96-9]
Formel:
C20H23N3O2
Target-Kategorie:
5-HT Receptor,Sigma Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
