S1RA (E-52862) is a highly selective sigma1 receptor (sigma1R) antagonist with Kis of 17 nM and 23.5 nM for human sigma1R and guinea pig sigma1R, respectively. S1RA has Moderate antagonistic activity for human 5-HT2B receptor (Ki= 328 nM). S1RA has antinociceptive effects in neuropathic pain models. S1RA prevents mechanical and cold hypersensitivity in Oxaliplatin (HY-17371)-treated mice[1][2].
Molecular Weight:
337.42
Purity:
99.43
CAS Number:
[878141-96-9]
Formula:
C20H23N3O2
Target:
5-HT Receptor,Sigma Receptor
Application Notes:
MCE Product type: Reference compound
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