LS-170 is a YEATS2 YEATS domain inhibitor with an IC50 of 0.14 µM. LS-170 displays selectivity for the YEATS2 YEATS domain over other YEATS domain family members and other epigenetic reader and eraser proteins. LS-170 reduces chromatin occupancy of the Ada-two-A-containing (ATAC) complex, decreases ATAC-dependent histone acetylation levels, and downregulates expression of ATAC-governed genes. LS-170 suppresses tumor growth in a lung cancer mouse model. LS-170 can be used for the research of non-small cell lung cancer[1].
Molekulargewicht:
764.70
CAS Nummer:
[3099617-79-2]
Formel:
C34H43BrFN5O7S
Target-Kategorie:
Epigenetic Reader Domain
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
