LS-170 is a YEATS2 YEATS domain inhibitor with an IC50 of 0.14 µM. LS-170 displays selectivity for the YEATS2 YEATS domain over other YEATS domain family members and other epigenetic reader and eraser proteins. LS-170 reduces chromatin occupancy of the Ada-two-A-containing (ATAC) complex, decreases ATAC-dependent histone acetylation levels, and downregulates expression of ATAC-governed genes. LS-170 suppresses tumor growth in a lung cancer mouse model. LS-170 can be used for the research of non-small cell lung cancer[1].
Molecular Weight:
764.70
CAS Number:
[3099617-79-2]
Formula:
C34H43BrFN5O7S
Target:
Epigenetic Reader Domain
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
