FLT3/HDAC-IN-3, CAS [[2864394-30-7]] Preis auf Anfrage

Produktübersicht

• Artikelname: FLT3/HDAC-IN-3, CAS [[2864394-30-7]] Preis auf Anfrage
• Artikelnummer: MCE-HY-181086
• Hersteller Artikelnummer: HY-181086
• Alternativnummer: MCE-HY-181086-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

FLT3/HDAC-IN-3 is a dual inhibitor of FLT3 and HDAC. FLT3/HDAC-IN-3 potently inhibits FLT3 (IC50 = 14 nM), HDAC1 (IC50 = 27 nM), HDAC6 (IC50 = 20 nM), and FLT3D853Y (IC50 = 55 nM), exhibits weak activity against HDAC8, and shows no activity against HDAC4. FLT3/HDAC-IN-3 possesses kinase selectivity, plasma stability, and stability in human liver microsomes. FLT3/HDAC-IN-3 demonstrates anti-proliferative effects in a variety of hematological malignancy cell lines. FLT3/HDAC-IN-3 shows efficacy in the Jeko-1 xenograft model without observed significant toxicity. FLT3/HDAC-IN-3 can be used in the study of hematological malignancies[1].

Produkteigenschaften

• Molekulargewicht: 445.53
• CAS Nummer: [2864394-30-7]
• Formel: C22H32FN7O2
• Target-Kategorie: Apoptosis,FLT3,HDAC,Reactive Oxygen Species (ROS)

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound