FLT3/HDAC-IN-3, CAS [[2864394-30-7]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-181086
Supplier Catalog Number:
HY-181086
Alternative Catalog Number:
MCE-HY-181086-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
FLT3/HDAC-IN-3 is a dual inhibitor of FLT3 and HDAC. FLT3/HDAC-IN-3 potently inhibits FLT3 (IC50 = 14 nM), HDAC1 (IC50 = 27 nM), HDAC6 (IC50 = 20 nM), and FLT3D853Y (IC50 = 55 nM), exhibits weak activity against HDAC8, and shows no activity against HDAC4. FLT3/HDAC-IN-3 possesses kinase selectivity, plasma stability, and stability in human liver microsomes. FLT3/HDAC-IN-3 demonstrates anti-proliferative effects in a variety of hematological malignancy cell lines. FLT3/HDAC-IN-3 shows efficacy in the Jeko-1 xenograft model without observed significant toxicity. FLT3/HDAC-IN-3 can be used in the study of hematological malignancies[1].
Molecular Weight:
445.53
CAS Number:
[2864394-30-7]
Formula:
C22H32FN7O2
Target:
Apoptosis,FLT3,HDAC,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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