PXS 64, a mannose-6-phosphate (M6P) analogue. a lipophilic prodrug of PXS 25 (HY-181430). PXS 64 is an effective anti-fibrotic agent by inhibiting the activation of latent TGF-beta1. PXS64, inhibits fibrosis via TGF-beta1 pathway in human lung fibroblasts. PXS 64 reduces TGFbeta-mediated collagen IV, fibronectin, MCP-1, and phospho-smad2 expression in kidney cells. PXS 64 reduces collagen deposition in dermal scar fibroblasts. PXS 64 can be used for the research of chronic kidney disease, idiopathic pulmonary fibrosis, scarring[1][2][3].
Molekulargewicht:
590.60
CAS Nummer:
[1253691-50-7]
Formel:
C27H43O12P
Target-Kategorie:
TGF-beta/Smad
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
