PXS 64, a mannose-6-phosphate (M6P) analogue. a lipophilic prodrug of PXS 25 (HY-181430). PXS 64 is an effective anti-fibrotic agent by inhibiting the activation of latent TGF-beta1. PXS64, inhibits fibrosis via TGF-beta1 pathway in human lung fibroblasts. PXS 64 reduces TGFbeta-mediated collagen IV, fibronectin, MCP-1, and phospho-smad2 expression in kidney cells. PXS 64 reduces collagen deposition in dermal scar fibroblasts. PXS 64 can be used for the research of chronic kidney disease, idiopathic pulmonary fibrosis, scarring[1][2][3].
Molecular Weight:
590.60
CAS Number:
[1253691-50-7]
Formula:
C27H43O12P
Target:
TGF-beta/Smad
Application Notes:
MCE Product type: Reference compound
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