CDK6-IN-2 is a CDK6 covalent inhibitor with an IC50 of 0.013 µM. CDK6-IN-2 inhibits the proliferation and migration of triple-negative breast cancer cells, and induces cell cycle arrest and apoptosis. CDK6-IN-2 induces ROS accumulation and mitochondrial damage through cellular metabolic reprogramming. CDK6-IN-2 exhibits anti-tumor activity and can be used for the research of triple-negative breast cancer[1].
Molekulargewicht:
529.43
Formel:
C24H29BrN6O3
Target-Kategorie:
Apoptosis,Autophagy,Caspase,CDK,Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
