CDK6-IN-2 is a CDK6 covalent inhibitor with an IC50 of 0.013 µM. CDK6-IN-2 inhibits the proliferation and migration of triple-negative breast cancer cells, and induces cell cycle arrest and apoptosis. CDK6-IN-2 induces ROS accumulation and mitochondrial damage through cellular metabolic reprogramming. CDK6-IN-2 exhibits anti-tumor activity and can be used for the research of triple-negative breast cancer[1].
Molecular Weight:
529.43
Formula:
C24H29BrN6O3
Target:
Apoptosis,Autophagy,Caspase,CDK,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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