EGFR-IN-197, CAS [[3060883-16-8]] Preis auf Anfrage

Produktübersicht

• Artikelname: EGFR-IN-197, CAS [[3060883-16-8]] Preis auf Anfrage
• Artikelnummer: MCE-HY-181502
• Hersteller Artikelnummer: HY-181502
• Alternativnummer: MCE-HY-181502-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

EGFR-IN-197 is an EGFR inhibitor with IC50 values of 19.5 nM and 12.0 nM against EGFRL858R/T790M and EGFRL858R/T790M/C797S, respectively. EGFR-IN-197 arrests the cell cycle of NCI-H1975 cells at the G2/M phase, while inhibiting their proliferation, colony formation and migration, it also inhibits mitochondrial translocation and upregulates mitochondrial H2S levels. EGFR-IN-197 disrupts anti-apoptotic signaling pathways by regulating apoptosis-related proteins, it induces DNA damage and activates pro-apoptotic pathways to trigger apoptosis. EGFR-IN-197 can be used in studies related to non-small cell lung cancer (NSCLC)[1].

Produkteigenschaften

• Molekulargewicht: 512.40
• CAS Nummer: [3060883-16-8]
• Formel: C23H26BrN7O2
• Target-Kategorie: Apoptosis,Bcl-2 Family,Caspase,EGFR,ERK,PARP

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound