EGFR-IN-197, CAS [[3060883-16-8]] Preis auf Anfrage

Product Overview

• Article Name: EGFR-IN-197, CAS [[3060883-16-8]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-181502
• Supplier Catalog Number: HY-181502
• Alternative Catalog Number: MCE-HY-181502-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

EGFR-IN-197 is an EGFR inhibitor with IC50 values of 19.5 nM and 12.0 nM against EGFRL858R/T790M and EGFRL858R/T790M/C797S, respectively. EGFR-IN-197 arrests the cell cycle of NCI-H1975 cells at the G2/M phase, while inhibiting their proliferation, colony formation and migration, it also inhibits mitochondrial translocation and upregulates mitochondrial H2S levels. EGFR-IN-197 disrupts anti-apoptotic signaling pathways by regulating apoptosis-related proteins, it induces DNA damage and activates pro-apoptotic pathways to trigger apoptosis. EGFR-IN-197 can be used in studies related to non-small cell lung cancer (NSCLC)[1].

Product Properties

• Molecular Weight: 512.40
• CAS Number: [3060883-16-8]
• Formula: C23H26BrN7O2
• Target: Apoptosis,Bcl-2 Family,Caspase,EGFR,ERK,PARP

Application Notes

• Application Notes: MCE Product type: Reference compound