JNK3-IN-10, CAS [[3085181-00-3]] Preis auf Anfrage

Produktübersicht

• Artikelname: JNK3-IN-10, CAS [[3085181-00-3]] Preis auf Anfrage
• Artikelnummer: MCE-HY-181556
• Hersteller Artikelnummer: HY-181556
• Alternativnummer: MCE-HY-181556-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

JNK3-IN-10 is a blood-brain barrier-impermeable JNK3 inhibitor (IC50=0.257 nM) with over 400-fold selectivity over JNK1. JNK3-IN-10 blocks the JNK3-mediated signaling pathway downstream of TGF-beta1, inhibits TGF-beta1-induced phosphorylation of c-Jun, reduces the expression of pro-fibrotic markers, and restores the expression of the epithelial protein E-cadherin. JNK3-IN-10 exhibits low cytotoxicity, anti-fibrotic, cytoprotective and renoprotective effects, and alleviates albuminuria, glomerulosclerosis and podocyte foot process fusion. JNK3-IN-10 can be used for the research of chronic kidney disease, glomerulosclerosis and adriamycin-induced nephropathy[1].

Produkteigenschaften

• Molekulargewicht: 559.47
• CAS Nummer: [3085181-00-3]
• Formel: C24H24Cl2N8O2S
• Target-Kategorie: Cadherin,JNK,TGF-beta/Smad

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound