JNK3-IN-10, CAS [[3085181-00-3]] Preis auf Anfrage

Product Overview

• Article Name: JNK3-IN-10, CAS [[3085181-00-3]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-181556
• Supplier Catalog Number: HY-181556
• Alternative Catalog Number: MCE-HY-181556-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

JNK3-IN-10 is a blood-brain barrier-impermeable JNK3 inhibitor (IC50=0.257 nM) with over 400-fold selectivity over JNK1. JNK3-IN-10 blocks the JNK3-mediated signaling pathway downstream of TGF-beta1, inhibits TGF-beta1-induced phosphorylation of c-Jun, reduces the expression of pro-fibrotic markers, and restores the expression of the epithelial protein E-cadherin. JNK3-IN-10 exhibits low cytotoxicity, anti-fibrotic, cytoprotective and renoprotective effects, and alleviates albuminuria, glomerulosclerosis and podocyte foot process fusion. JNK3-IN-10 can be used for the research of chronic kidney disease, glomerulosclerosis and adriamycin-induced nephropathy[1].

Product Properties

• Molecular Weight: 559.47
• CAS Number: [3085181-00-3]
• Formula: C24H24Cl2N8O2S
• Target: Cadherin,JNK,TGF-beta/Smad

Application Notes

• Application Notes: MCE Product type: Reference compound