PROTAC Aurora A Degrader-1, CAS [[3115344-59-4]] Preis auf Anfrage

Produktübersicht

• Artikelname: PROTAC Aurora A Degrader-1, CAS [[3115344-59-4]] Preis auf Anfrage
• Artikelnummer: MCE-HY-181568
• Hersteller Artikelnummer: HY-181568
• Alternativnummer: MCE-HY-181568-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC Aurora A Degrader-1 (Compound 280) is a blood-brain barrier-permeable selective Aurora A PROTAC degrader, with DC50 values of 1 nM and 2 nM in LAN5 and SMS-SAN cells, respectively. PROTAC Aurora A Degrader-1 induces the formation of a ternary complex between AURKA and CRBN, degrades AURKA, reduces MYCN levels, induces DNA damage and apoptosis, exerts antiproliferative activity in cancer cells, and regulates the immune system. PROTAC Aurora A Degrader-1 is applicable to the research of neuroblastoma and small cell lung cancer[1].

Produkteigenschaften

• Molekulargewicht: 723.27
• CAS Nummer: [3115344-59-4]
• Formel: C38H43ClN10O3
• Target-Kategorie: Apoptosis,Aurora Kinase,DNA/RNA Synthesis,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound