PROTAC Aurora A Degrader-1, CAS [[3115344-59-4]] Preis auf Anfrage

Product Overview

• Article Name: PROTAC Aurora A Degrader-1, CAS [[3115344-59-4]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-181568
• Supplier Catalog Number: HY-181568
• Alternative Catalog Number: MCE-HY-181568-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

PROTAC Aurora A Degrader-1 (Compound 280) is a blood-brain barrier-permeable selective Aurora A PROTAC degrader, with DC50 values of 1 nM and 2 nM in LAN5 and SMS-SAN cells, respectively. PROTAC Aurora A Degrader-1 induces the formation of a ternary complex between AURKA and CRBN, degrades AURKA, reduces MYCN levels, induces DNA damage and apoptosis, exerts antiproliferative activity in cancer cells, and regulates the immune system. PROTAC Aurora A Degrader-1 is applicable to the research of neuroblastoma and small cell lung cancer[1].

Product Properties

• Molecular Weight: 723.27
• CAS Number: [3115344-59-4]
• Formula: C38H43ClN10O3
• Target: Apoptosis,Aurora Kinase,DNA/RNA Synthesis,PROTACs

Application Notes

• Application Notes: MCE Product type: Reference compound