MDH2-IN-2 is an orally active MDH2 inhibitor with an IC50 of 5.9 µM. MDH2-IN-2 reduces the levels of senescence markers and senescence-associated secretory phenotype (SASP) factors in mammalian cell models. MDH2-IN-2 extends the lifespan and improves the healthspan of *Caenorhabditis elegans*. MDH2-IN-2 alleviates tissue senescence in aged mice, inhibits SASP factors, and restores liver and kidney functions. MDH2-IN-2 is applicable for senescence-related research[1].
Molekulargewicht:
536.73
CAS Nummer:
[3047410-41-0]
Formel:
C31H40N2O4S
Target-Kategorie:
Malate Dehydrogenase (MDH)
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
