MDH2-IN-2 is an orally active MDH2 inhibitor with an IC50 of 5.9 µM. MDH2-IN-2 reduces the levels of senescence markers and senescence-associated secretory phenotype (SASP) factors in mammalian cell models. MDH2-IN-2 extends the lifespan and improves the healthspan of *Caenorhabditis elegans*. MDH2-IN-2 alleviates tissue senescence in aged mice, inhibits SASP factors, and restores liver and kidney functions. MDH2-IN-2 is applicable for senescence-related research[1].
Molecular Weight:
536.73
CAS Number:
[3047410-41-0]
Formula:
C31H40N2O4S
Target:
Malate Dehydrogenase (MDH)
Application Notes:
MCE Product type: Reference compound
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