SHP2-IN-47 is a selective and potent SHP2 inhibitor with an IC50 of 0.80 µM. SHP2-IN-47 exhibits potent inhibitory activity against SHP2E76K (IC50 = 0.37 µM). SHP2-IN-47 functionally inhibits protein tyrosine phosphatase domains and downregulates SHP2-mediated phosphorylation of AKT and ERK. SHP2-IN-47 induces apoptosis and suppresses proliferation of cancer cells. SHP2-IN-47 can be used for the research of cancer, such as acute myelocytic leukemia[1].
Molekulargewicht:
738.75
Formel:
C34H37Cl2N9O2S2
Target-Kategorie:
Akt,Apoptosis,ERK,SHP2
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
