SHP2-IN-47 is a selective and potent SHP2 inhibitor with an IC50 of 0.80 µM. SHP2-IN-47 exhibits potent inhibitory activity against SHP2E76K (IC50 = 0.37 µM). SHP2-IN-47 functionally inhibits protein tyrosine phosphatase domains and downregulates SHP2-mediated phosphorylation of AKT and ERK. SHP2-IN-47 induces apoptosis and suppresses proliferation of cancer cells. SHP2-IN-47 can be used for the research of cancer, such as acute myelocytic leukemia[1].
Molecular Weight:
738.75
Formula:
C34H37Cl2N9O2S2
Target:
Akt,Apoptosis,ERK,SHP2
Application Notes:
MCE Product type: Reference compound
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