F44-S101 is an orally active, potent, and selective gut-restricted FXR antagonist with an IC50 of 0.48 µM and lipid-lowering activity. F44-S101 selectively antagonizes intestinal FXR, feedback-activates hepatic FXR, promotes cholesterol metabolism and reduces lipid accumulation.F44-S101 decreases total cholesterol, triglyceride and low-density lipoprotein cholesterol levels. F44-S101 can be used in studies related to hyperlipidemia[1].
Molekulargewicht:
573.08
Formel:
C27H25ClN2O6S2
Target-Kategorie:
FXR
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
