F44-S101 is an orally active, potent, and selective gut-restricted FXR antagonist with an IC50 of 0.48 µM and lipid-lowering activity. F44-S101 selectively antagonizes intestinal FXR, feedback-activates hepatic FXR, promotes cholesterol metabolism and reduces lipid accumulation.F44-S101 decreases total cholesterol, triglyceride and low-density lipoprotein cholesterol levels. F44-S101 can be used in studies related to hyperlipidemia[1].
Molecular Weight:
573.08
Formula:
C27H25ClN2O6S2
Target:
FXR
Application Notes:
MCE Product type: Reference compound
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