PROTAC mHTT Degrader-1, CAS [[2919475-43-5]] Preis auf Anfrage

Produktübersicht

• Artikelname: PROTAC mHTT Degrader-1, CAS [[2919475-43-5]] Preis auf Anfrage
• Artikelnummer: MCE-HY-181879
• Hersteller Artikelnummer: HY-181879
• Alternativnummer: MCE-HY-181879-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

PROTAC mHTT Degrader-1 is a blood-brain barrier-penetrant mutant huntingtin (mHTT) PROTAC degrader. PROTAC mHTT Degrader-1 specifically recognizes pathogenic mHTT aggregates and recruits Cereblon (CRBN), thereby inducing ubiquitination and proteasomal degradation of mHTT. PROTAC mHTT Degrader-1 alleviates mHTT-induced cytotoxicity and neuroinflammation. In the R6/2 Huntingtons disease mouse model, PROTAC mHTT Degrader-1 reduces cerebral protein aggregation levels and improves body weight, motor coordination and survival rate of animals. PROTAC mHTT Degrader-1 can be used for research on PROTAC therapies for Huntingtons disease and other neurodegenerative diseases[1].

Produkteigenschaften

• Molekulargewicht: 613.66
• CAS Nummer: [2919475-43-5]
• Formel: C33H35N5O7
• Target-Kategorie: Huntingtin,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound