PROTAC mHTT Degrader-1, CAS [[2919475-43-5]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-181879
Supplier Catalog Number:
HY-181879
Alternative Catalog Number:
MCE-HY-181879-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
PROTAC mHTT Degrader-1 is a blood-brain barrier-penetrant mutant huntingtin (mHTT) PROTAC degrader. PROTAC mHTT Degrader-1 specifically recognizes pathogenic mHTT aggregates and recruits Cereblon (CRBN), thereby inducing ubiquitination and proteasomal degradation of mHTT. PROTAC mHTT Degrader-1 alleviates mHTT-induced cytotoxicity and neuroinflammation. In the R6/2 Huntingtons disease mouse model, PROTAC mHTT Degrader-1 reduces cerebral protein aggregation levels and improves body weight, motor coordination and survival rate of animals. PROTAC mHTT Degrader-1 can be used for research on PROTAC therapies for Huntingtons disease and other neurodegenerative diseases[1].
Molecular Weight:
613.66
CAS Number:
[2919475-43-5]
Formula:
C33H35N5O7
Target:
Huntingtin,PROTACs
Application Notes:
MCE Product type: Reference compound
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