Nrf2 activator-23, CAS [[3109883-60-2]] Preis auf Anfrage

Produktübersicht

• Artikelname: Nrf2 activator-23, CAS [[3109883-60-2]] Preis auf Anfrage
• Artikelnummer: MCE-HY-181887
• Hersteller Artikelnummer: HY-181887
• Alternativnummer: MCE-HY-181887-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

Nrf2 activator-23 is an orally active Keap1 binder and Nrf2 activator, with KD values of 28.68 nM and 54.55 nM for Keap1 and its Kelch domain, respectively. Nrf2 activator-23 disrupts the Keap1-Nrf2 interaction, reduces ubiquitination and degradation of Nrf2, and activates the Nrf2 signaling pathway. Nrf2 activator-23 inhibits RANKL-induced osteoclast formation, bone resorptive activity, ROS production, and activation of the MAPK and NF-kappaB signaling pathways, while downregulating the expression of osteoclast-specific genes and proteins. Nrf2 activator-23 attenuates bone loss and reduces osteoclast formation in vivo without affecting osteoblast differentiation and mineralization. Nrf2 activator-23 can be used for the research of osteoporosis[1].

Produkteigenschaften

• Molekulargewicht: 423.34
• CAS Nummer: [3109883-60-2]
• Formel: C23H17FO2Se

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound