Nrf2 activator-23, CAS [[3109883-60-2]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-181887
Supplier Catalog Number:
HY-181887
Alternative Catalog Number:
MCE-HY-181887-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Nrf2 activator-23 is an orally active Keap1 binder and Nrf2 activator, with KD values of 28.68 nM and 54.55 nM for Keap1 and its Kelch domain, respectively. Nrf2 activator-23 disrupts the Keap1-Nrf2 interaction, reduces ubiquitination and degradation of Nrf2, and activates the Nrf2 signaling pathway. Nrf2 activator-23 inhibits RANKL-induced osteoclast formation, bone resorptive activity, ROS production, and activation of the MAPK and NF-kappaB signaling pathways, while downregulating the expression of osteoclast-specific genes and proteins. Nrf2 activator-23 attenuates bone loss and reduces osteoclast formation in vivo without affecting osteoblast differentiation and mineralization. Nrf2 activator-23 can be used for the research of osteoporosis[1].
Molecular Weight:
423.34
CAS Number:
[3109883-60-2]
Formula:
C23H17FO2Se
Application Notes:
MCE Product type: Reference compound
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