KRAS G12C-IN-77, CAS [[3023465-19-9]] Preis auf Anfrage

Produktübersicht

• Artikelname: KRAS G12C-IN-77, CAS [[3023465-19-9]] Preis auf Anfrage
• Artikelnummer: MCE-HY-181964
• Hersteller Artikelnummer: HY-181964
• Alternativnummer: MCE-HY-181964-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

KRAS G12C-IN-77 is an orally active and selective KRASG12C covalent dual-state inhibitor that binds with high affinity to both GDP-bound (inactive state) and GTP-bound (active state) KRASG12C (IC50 = 133 nM). KRAS G12C-IN-77 rapidly inhibits ERK1/2 phosphorylation, induces the formation of covalent adducts with endogenous KRASG12C, suppresses the expression of MAPK pathway genes, and inhibits the proliferation of KRASG12C-mutant cells. KRAS G12C-IN-77 is applicable to research related to KRASG12C-mutant solid tumors, including pancreatic ductal adenocarcinoma and non-small cell lung cancer[1].

Produkteigenschaften

• Molekulargewicht: 689.73
• CAS Nummer: [3023465-19-9]
• Formel: C39H34F3N7O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound