KRAS G12C-IN-77, CAS [[3023465-19-9]] Preis auf Anfrage

Product Overview

• Article Name: KRAS G12C-IN-77, CAS [[3023465-19-9]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-181964
• Supplier Catalog Number: HY-181964
• Alternative Catalog Number: MCE-HY-181964-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

KRAS G12C-IN-77 is an orally active and selective KRASG12C covalent dual-state inhibitor that binds with high affinity to both GDP-bound (inactive state) and GTP-bound (active state) KRASG12C (IC50 = 133 nM). KRAS G12C-IN-77 rapidly inhibits ERK1/2 phosphorylation, induces the formation of covalent adducts with endogenous KRASG12C, suppresses the expression of MAPK pathway genes, and inhibits the proliferation of KRASG12C-mutant cells. KRAS G12C-IN-77 is applicable to research related to KRASG12C-mutant solid tumors, including pancreatic ductal adenocarcinoma and non-small cell lung cancer[1].

Product Properties

• Molecular Weight: 689.73
• CAS Number: [3023465-19-9]
• Formula: C39H34F3N7O2

Application Notes

• Application Notes: MCE Product type: Reference compound