VEGFR2-IN-84, CAS [[861877-12-5]] Preis auf Anfrage

Produktübersicht

• Artikelname: VEGFR2-IN-84, CAS [[861877-12-5]] Preis auf Anfrage
• Artikelnummer: MCE-HY-182354
• Hersteller Artikelnummer: HY-182354
• Alternativnummer: MCE-HY-182354-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

VEGFR2-IN-84 is an orally active, multi-targeted tyrosine kinase inhibitor based on a naphthalene ring scaffold. VEGFR2-IN-84 inhibits VEGFR2 with sub-nanomolar affinity and broadly targets kinases including Kit, FGFR, PDGFR, and Ret. By competitively binding to the ATP-binding pocket, VEGFR2-IN-84 blocks the phosphorylation of VEGFR2 and its downstream AKT/ERK signaling pathway, thereby significantly inhibiting endothelial cell proliferation, migration, and tumor angiogenesis. VEGFR2-IN-84 exhibits broad-spectrum antiproliferative activity against various solid tumors such as liver cancer, lung cancer, and renal cancer, shows weak toxicity to normal cells, and has superior potency to Lenvatinib (HY-10981). VEGFR2-IN-84 possesses favorable pharmacokinetic properties and high safety (LD50>2000 mg/kg), and can be used in related studies of various malignant tumors[1].

Produkteigenschaften

• Molekulargewicht: 470.50
• CAS Nummer: [861877-12-5]
• Formel: C25H18N4O4S
• Target-Kategorie: Akt,c-Kit,ERK,FGFR,FLT3,PDGFR,RET,VEGFR

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound