VEGFR2-IN-84, CAS [[861877-12-5]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-182354
Supplier Catalog Number:
HY-182354
Alternative Catalog Number:
MCE-HY-182354-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
VEGFR2-IN-84 is an orally active, multi-targeted tyrosine kinase inhibitor based on a naphthalene ring scaffold. VEGFR2-IN-84 inhibits VEGFR2 with sub-nanomolar affinity and broadly targets kinases including Kit, FGFR, PDGFR, and Ret. By competitively binding to the ATP-binding pocket, VEGFR2-IN-84 blocks the phosphorylation of VEGFR2 and its downstream AKT/ERK signaling pathway, thereby significantly inhibiting endothelial cell proliferation, migration, and tumor angiogenesis. VEGFR2-IN-84 exhibits broad-spectrum antiproliferative activity against various solid tumors such as liver cancer, lung cancer, and renal cancer, shows weak toxicity to normal cells, and has superior potency to Lenvatinib (HY-10981). VEGFR2-IN-84 possesses favorable pharmacokinetic properties and high safety (LD50>2000 mg/kg), and can be used in related studies of various malignant tumors[1].
Molecular Weight:
470.50
CAS Number:
[861877-12-5]
Formula:
C25H18N4O4S
Target:
Akt,c-Kit,ERK,FGFR,FLT3,PDGFR,RET,VEGFR
Application Notes:
MCE Product type: Reference compound
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