NUAK1-IN-3, CAS [[3097515-05-1]] Preis auf Anfrage

Produktübersicht

• Artikelname: NUAK1-IN-3, CAS [[3097515-05-1]] Preis auf Anfrage
• Artikelnummer: MCE-HY-182361
• Hersteller Artikelnummer: HY-182361
• Alternativnummer: MCE-HY-182361-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

NUAK1-IN-3 is a potent and selective NUAK1 inhibitor with an IC50 of 0.49 nM. NUAK1-IN-3 also inhibits NUAK2 and JAK3 with IC50 values of 265 and 225 nM. NUAK1-IN-3 engages Glu139 of NUAK1, forms a salt bridge between its bicyclic ring nitrogen and Asp142, and uses a fluorine atom to enhance hydrophobic binding interactions. NUAK1-IN-3 attenuates MYPT1 phosphorylation, suppresses the NUAK1-MYPT1 signaling axis, and inhibits proliferation, migration, and invasion of triple-negative breast cancer cells. NUAK1-IN-3 reverses TGF-beta1-induced epithelial-mesenchymal transition (EMT) marker alterations, downregulates Snail and N-cadherin, and upregulates E-cadherin in tumor tissues. NUAK1-IN-3 suppresses tumor growth in triple-negative breast cancer xenograft models. NUAK1-IN-3 can be used for the research of triple-negative breast cancer[1].

Produkteigenschaften

• Molekulargewicht: 644.09
• CAS Nummer: [3097515-05-1]
• Formel: C30H35ClFN7O6
• Target-Kategorie: AMPK,Cadherin,JAK

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound