NUAK1-IN-3, CAS [[3097515-05-1]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-182361
Supplier Catalog Number:
HY-182361
Alternative Catalog Number:
MCE-HY-182361-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
NUAK1-IN-3 is a potent and selective NUAK1 inhibitor with an IC50 of 0.49 nM. NUAK1-IN-3 also inhibits NUAK2 and JAK3 with IC50 values of 265 and 225 nM. NUAK1-IN-3 engages Glu139 of NUAK1, forms a salt bridge between its bicyclic ring nitrogen and Asp142, and uses a fluorine atom to enhance hydrophobic binding interactions. NUAK1-IN-3 attenuates MYPT1 phosphorylation, suppresses the NUAK1-MYPT1 signaling axis, and inhibits proliferation, migration, and invasion of triple-negative breast cancer cells. NUAK1-IN-3 reverses TGF-beta1-induced epithelial-mesenchymal transition (EMT) marker alterations, downregulates Snail and N-cadherin, and upregulates E-cadherin in tumor tissues. NUAK1-IN-3 suppresses tumor growth in triple-negative breast cancer xenograft models. NUAK1-IN-3 can be used for the research of triple-negative breast cancer[1].
Molecular Weight:
644.09
CAS Number:
[3097515-05-1]
Formula:
C30H35ClFN7O6
Target:
AMPK,Cadherin,JAK
Application Notes:
MCE Product type: Reference compound
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