TNF-alpha-IN-29 is an orally active and selective TNF-alpha inhibitor, with IC50 values of 123.0 nM against human targets, and a human Kd of 45.9 nM. TNF-alpha-IN-29 blocks TNF-alpha-TNFR1 protein-protein interactions and inhibits TNF-alpha-mediated inflammatory signaling pathways. TNF-alpha-IN-29 exhibits anti-inflammatory effects in a mouse model of collagen-induced arthritis and promotes articular cartilage repair. TNF-alpha-IN-29 can be used for the research of rheumatoid arthritis[1].
Molekulargewicht:
582.02
Formel:
C29H27ClF3N7O
Target-Kategorie:
TNF Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
