TNF-alpha-IN-29 is an orally active and selective TNF-alpha inhibitor, with IC50 values of 123.0 nM against human targets, and a human Kd of 45.9 nM. TNF-alpha-IN-29 blocks TNF-alpha-TNFR1 protein-protein interactions and inhibits TNF-alpha-mediated inflammatory signaling pathways. TNF-alpha-IN-29 exhibits anti-inflammatory effects in a mouse model of collagen-induced arthritis and promotes articular cartilage repair. TNF-alpha-IN-29 can be used for the research of rheumatoid arthritis[1].
Molecular Weight:
582.02
Formula:
C29H27ClF3N7O
Target:
TNF Receptor
Application Notes:
MCE Product type: Reference compound
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