NGI-189 is a selective OST-A inhibitor. NGI-189 inhibits the STT3A catalytic subunit of the OST complex and reduces N-glycosylation of target glycoproteins. NGI-189 blocks oncogenic and bypass signaling, reduces phosphorylation of EGFR, AKT, p70S6K and S6RP, and induces cell cycle arrest and apoptosis. NGI-189 markedly suppresses tumor growth and induces tumor regression in non-small cell lung cancer (NSCLC) xenograft models. NGI-189 can be used for the research of EGFR-mutant non-small cell lung cancer[1].
Molekulargewicht:
478.63
Reinheit:
99.29
CAS Nummer:
[2763063-26-7]
Formel:
C22H30N4O4S2
Target-Kategorie:
Akt,Apoptosis,Bcl-2 Family,EGFR
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
