NGI-189 is a selective OST-A inhibitor. NGI-189 inhibits the STT3A catalytic subunit of the OST complex and reduces N-glycosylation of target glycoproteins. NGI-189 blocks oncogenic and bypass signaling, reduces phosphorylation of EGFR, AKT, p70S6K and S6RP, and induces cell cycle arrest and apoptosis. NGI-189 markedly suppresses tumor growth and induces tumor regression in non-small cell lung cancer (NSCLC) xenograft models. NGI-189 can be used for the research of EGFR-mutant non-small cell lung cancer[1].
Molecular Weight:
478.63
Purity:
99.29
CAS Number:
[2763063-26-7]
Formula:
C22H30N4O4S2
Target:
Akt,Apoptosis,Bcl-2 Family,EGFR
Application Notes:
MCE Product type: Reference compound
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