Isosorbide di-(methyl fumarate), CAS [[2013542-44-2]]

Produktübersicht

• Artikelname: Isosorbide di-(methyl fumarate), CAS [[2013542-44-2]]
• Artikelnummer: MCE-HY-183326
• Hersteller Artikelnummer: HY-183326
• Alternativnummer: MCE-HY-183326-5MG, MCE-HY-183326-10MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: IDMF

Produktbeschreibung

Isosorbide di-(methyl fumarate) (IDMF), topical DMF (HY-17363) derivative, is an NRF2/ARE pathway activator. Isosorbide di-(methyl fumarate) downregulates ANCR targets, modulates epithelial differentiation, represses proinflammatory cytokine genes, IL-17A- and TNF-induced keratinocyte genes, psoriatic skin lesion-specific genes, and immune response genes. Isosorbide di-(methyl fumarate) stimulates oxidative stress response gene transcription, reduces erythema and scaling in Imiquimod (HY-B0180)-induced psoriasiform lesions. Isosorbide di-(methyl fumarate) exhibits no genotoxicity or radiation sensitivity in skin fibroblasts, is nonirritating and nonsensitizing in rodent models. Isosorbide di-(methyl fumarate) can be used for the research of psoriasis vulgaris[1].

Produkteigenschaften

• Molekulargewicht: 370.31
• Reinheit: 99.87
• CAS Nummer: [2013542-44-2]
• Formel: C16H18O10
• Target-Kategorie: Keap1-Nrf2

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound