Isosorbide di-(methyl fumarate), CAS [[2013542-44-2]]

Product Overview

• Article Name: Isosorbide di-(methyl fumarate), CAS [[2013542-44-2]]
• Biozol Catalog Number: MCE-HY-183326
• Supplier Catalog Number: HY-183326
• Alternative Catalog Number: MCE-HY-183326-5MG, MCE-HY-183326-10MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: IDMF

Product Description

Isosorbide di-(methyl fumarate) (IDMF), topical DMF (HY-17363) derivative, is an NRF2/ARE pathway activator. Isosorbide di-(methyl fumarate) downregulates ANCR targets, modulates epithelial differentiation, represses proinflammatory cytokine genes, IL-17A- and TNF-induced keratinocyte genes, psoriatic skin lesion-specific genes, and immune response genes. Isosorbide di-(methyl fumarate) stimulates oxidative stress response gene transcription, reduces erythema and scaling in Imiquimod (HY-B0180)-induced psoriasiform lesions. Isosorbide di-(methyl fumarate) exhibits no genotoxicity or radiation sensitivity in skin fibroblasts, is nonirritating and nonsensitizing in rodent models. Isosorbide di-(methyl fumarate) can be used for the research of psoriasis vulgaris[1].

Product Properties

• Molecular Weight: 370.31
• Purity: 99.87
• CAS Number: [2013542-44-2]
• Formula: C16H18O10
• Target: Keap1-Nrf2

Application Notes

• Application Notes: MCE Product type: Reference compound