(R)-CR8 (trihydrochloride), CAS [[1786438-30-9]]

Produktübersicht

• Artikelname: (R)-CR8 (trihydrochloride), CAS [[1786438-30-9]]
• Artikelnummer: MCE-HY-18340A
• Hersteller Artikelnummer: HY-18340A
• Alternativnummer: MCE-HY-18340A-50MG,MCE-HY-18340A-25MG,MCE-HY-18340A-10MMX1ML,MCE-HY-18340A-10MG,MCE-HY-18340A-100MG,MCE-HY-18340A-5MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: CR8, (R)-Isomer (trihydrochloride)

Produktbeschreibung

(R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 µM), CDK2/cyclin A (0.072 µM), CDK2/cyclin E (0.041 µM), CDK5/p25 (0.11 µM), CDK7/cyclin H (1.1 µM), CDK9/cyclin T (0.18 µM) and CK1delta/epsilon (0.4 µM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect[1][2]. (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K[3].

Produkteigenschaften

• Molekulargewicht: 540.92
• Reinheit: 99.37
• CAS Nummer: [1786438-30-9]
• Formel: C24H32Cl3N7O
• Target-Kategorie: Apoptosis,CDK,Molecular Glues

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound